5 WARNINGS AND PRECAUTIONS

Sildenafil > sildenafil citrate tables


This is not a complete list of possible interactions. Do not use other medications for impotence (e.g. alprostadil or yohimbine) without consulting a healthcare professional. This medication may not be suitable for people with certain conditions, so it is important to consult with a doctor if you have any health conditions.

Parameter Value Notes
Absorption Time 30-120 minutes Peak plasma levels in approx. 1 hour
Bioavailability About 40% Due to first-pass metabolism
T1/2 (Half-life) 4-5 hours Eliminated mainly via hepatic metabolism
Onset of Action 30-60 minutes Varies with food intake
Duration of Effect Up to 4-6 hours Depending on dose and individual

Special considerations, such as lower dosages or regular monitoring, may be necessary for conditions like: hematological disorders with a predisposition for priapism pulmonary hypertension secondary to sickle-cell disease eye problems, such as blindness in one or both eyes blood cell disorders, such as sickle cell anemia, multiple myeloma, or leukemia It is recommended to avoid grapefruit products while taking sildenafil.

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Grapefruit may interact with this drug and cause increased negative side effects.

5.6 Combination with Other PDE-5 Inhibitors

As this population is more likely to have medical conditions, it is advised to use a lower starting dose. This medication should be stored at room temperature between 15-30°C. Keep the tablets out of the reach of children and pets. For patients taking CYP3A4 inhibitors, the starting dose should be not more than 25mg per day. For patients taking ritonavir-boosted HIV inhibitors, the maximum dosage is 25mg in 48 hours.

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For stable patients taking alpha-blockers, the starting dose should be 25mg. It is advised to monitor blood pressure and pulse when this drug is used with hypotensive medications. The combination of Sildenafil with nitrate and nicorandil can lead to a significant drop in blood pressure, which can potentially be fatal. As with all pharmaceuticals, some unwanted effects can occur from the use of Sildenafil Citrate Tablets. Common side effects include, but may not be limited to: Seek medical attention if the following symptoms develop: blurred vision or sudden loss of vision ringing in the ears or a sudden decrease or loss of hearing erection that lasts longer than 4 hours For a comprehensive understanding of all potential side effects, consult a medical professional. Alcohol should be avoided while taking sildenafil, as this combination can significantly increase the risk of certain side effects such as hypotension.

  • Physical activity might improve erectile response when combined with medication.
  • Maintain a healthy weight for better sexual function.
  • Lifestyle changes can enhance sildenafil efficacy over time.

Long-term effect of sildenafil citrate on erectile dysfunction after radical prostatectomy: 3-year follow-up This study assesses the long-term efficacy and safety of sildenafil citrate for treating erectile dysfunction following radical prostatectomy (RP). Ninety-one patients with post-RP erectile dysfunction were included in the study. They were prescribed oral sildenafil citrate and surveyed using a self-administered questionnaire during the first year of treatment to evaluate treatment satisfaction, compliance, and safety.

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After three years, a follow-up survey was conducted with 48 patients who had responded positively to the drug. Sildenafil citrate was initially prescribed at a dose of 50mg, with a possible increase to 100mg based on need. At the three-year mark, 71% of the respondents were still responding to sildenafil. Among these patients, 31% had increased their dosage to 100mg. The dropout rate was 27%, with reasons including the return of natural erections, loss of efficacy, and personal circumstances. The conclusion of this study is that the majority of patients with post-RP erectile dysfunction who initially respond to sildenafil continue to do so at three years. Treated patients with sildenafil citrate remain satisfied and compliant with the treatment.

5.7 Combination with other PDE5 Inhibitors or Other Erectile Dysfunction Therapies

The maximum dosage is 120mg per day. Renal Dosing for pediatrics No adjustment is needed for children with renal impairment. Dosing adjustment guidelines have not been defined for pediatric patients with HD/PD. Hepatic Dosing for pediatrics No adjustment is needed for children with Child-Pugh Class A or B. Dosing adjustment guidelines have been defined for pediatric patients with Child-Pugh Class C.

Professional resources

The dosage is based on medical condition, response to treatment, age, and weight. Refer to a doctor or pharmacist for guidelines on dosage. When taken for erectile dysfunction, this drug is used as needed so it is unlikely to be forgotten. When taken for pulmonary arterial hypertension, the forgotten dose should be taken as soon as it is remembered. If it is nearly time for the next scheduled dose, then the missed dose should be skipped. For those of you taking Sildenafil (Viagra) to help with ED, I am asking this dosing question. I just got my first script from the online pharmacy my doctor sent it to, and the bottle says "Take two pills daily and 3 more 1 hour before sexual activity." And then on the "appointed day" take 5?

  • Sildenafil is generally safe when used as prescribed.
  • Always follow your healthcare provider’s dosage instructions.
  • Do not double doses if a dose is missed.

Go to the Prostate Cancer Support Group. It seems to be common to do this to try and resolve ED issues. I'm not a medical professional, but here's a document on UCSF that someone on this blog mentioned in another thread. It has a section on Penile Rehabilitation that includes some information related to your question: Best wishes. I would think your doctor would’ve checked up before prescribing it for you though, but you never know.

8.2 Lactation

You have a history of heart attack or stroke in the past six months. You have known hereditary degenerative retinal disorders such as retinitis pigmentosa. Drug interactions may increase your risk for serious side effects or change how your medications work. Consult with your doctor about any vitamins, supplements, or medications you are taking before treatment with sildenafil citrate. This drug is known to interact with medications for hypertension or prostate problems, antifungals (e.g. You should at least mention to your doctor, the side effects you have felt from taking the drug. See what he has to say about it.

Overdose/Missed Dose

Sildenafil Citrate Tablets can be given to adults and children, but caution is advised for specific groups of patients. Pregnant It is not known whether Sildenafil causes fetal harm. It is important to note that pulmonary hypertension increases the risk of complications during pregnancy, including heart failure or stroke, for both the mother and fetus. Sildenafil should be used if the benefits outweigh the risks under medical discretion. Breastfeeding This drug should be used if the benefits outweigh the risks.

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Though harm is not expected based on the drug properties, inadequate human data is available to evaluate the risk of infant harm. There is no human data available that addresses this drug’s effects on milk production. Children It is advised to avoid high-dose therapy with Sildenafil in pediatric patients, as there is a greater risk of mortality. Geriatric When used to treat erectile dysfunction, Sildenafil is typically well tolerated by healthy elderly male patients. Studies have not shown significant differences in response but have reported that healthy elderly patients show a reduced clearance of the drug that could increase the risk of adverse effects. Yes, and I have spoken to her.

5.4 Visual Loss

Renal Dosing For erectile dysfunction, a starting dose of 25mg should be considered for patients with severe renal impairment (CrCl < 30). Dosing adjustment guidelines have not been defined for patients with HD/PD. For pulmonary arterial hypertension, no adjustment is needed for patients with renal impairment. Hepatic Dosing For erectile dysfunction, a starting dose of 25mg should be considered for patients with hepatic impairment or cirrhosis. For pulmonary arterial hypertension, no adjustment is needed for patients with Child-Pugh Class A or B.

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Dosing adjustment guidelines have not been defined for patients with Child-Pugh Class C. Pediatric Dosing For pulmonary arterial hypertension, doses for pediatric patients from 1 to 17 years old are based on body weight. body weight < 20kg: 10mg taken 3 times per day. body weight 20-45kg: 20mg taken 3 times per day. body weight > 45kg: 20mg taken 3 times per day. The sildenafil is for "lung blood pressure", whatever that means. It has not impacted my pulse rate or my BP. I think I'm just sensitive to it.

What is sildenafil?

If any symptoms persist or worsen, or you notice any other symptoms, please call your doctor immediately. Do NOT use Sildenafil Citrate Tablets if: You are allergic to sildenafil or any of the other ingredients. You are taking a nitrate drug, such as nitroglycerin, isosorbide dinitrate, or or isosorbide mononitrate. You blue sildenafil have been advised to currently refrain from sexual activity. You have vision loss due to non-arteritic anterior ischaemic optic neuropathy. It can cause problems if you normally have low blood pressure.

Frequently asked questions

This medication is intended to be taken orally. It can be taken with or without food, but a high-fat meal may delay the drug's activity. Adult Dosing For erectile dysfunction, the usual dose is 25-100mg taken 30 minutes to 4 hours before sexual activity. It is recommended to consider a starting dose of 25mg in patients over 65 years old. For pulmonary arterial hypertension, the usual dose is 20mg taken 3 times per day.

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Doses should be taken 4-6 hours apart. Geriatric Dosing For erectile dysfunction in patients 65 years or older, the usual starting dose is 25mg 30 minutes to 4 hours before sexual activity. The dose can be increased based on tolerance and effectiveness. The maximum dosage is 100mg per day. The dose can be increased up to 80mg taken 3 times per day. VIAGRA is indicated for the treatment of erectile dysfunction. VIAGRA is a phosphodiesterase-5 (PDE5) inhibitor indicated for the treatment of erectile dysfunction (ED) (1) For most patients, the recommended dose is 50 mg taken, as needed, approximately 1 hour before sexual activity. However, VIAGRA may be taken anywhere from 30 minutes to 4 hours before sexual activity (2.1) Based on effectiveness and toleration, may increase to a maximum of 100 mg or decrease to 25 mg (2.1) Maximum recommended dosing frequency is once per day (2.1) For most patients, the recommended dose is 50 mg taken, as needed, approximately 1 hour before sexual activity. However, VIAGRA may be taken anywhere from 30 minutes to 4 hours before sexual activity. VIAGRA may be taken with or without food.