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Product Specification

[33] The reasons behind such use include the belief that the drug increases libido, improves sexual performance,[33] or permanently increases penis size. [34] Studies on the effects of sildenafil when used recreationally are limited, but suggest it has little effect when used by those who do not have erectile dysfunction. In one study, a 25 mg dose was shown to cause no significant change in erectile quality, but did reduce the postejaculatory refractory time. [35] This study also noted a significant placebo effect in the control group. Unprescribed recreational use of sildenafil and other PDE5 inhibitors is noted as particularly high among users of illegal drugs.

Phonetic Name

[36] Sildenafil is sometimes used to counteract the effects of other substances, often illicit. [33] Some users mix it with methylenedioxymethamphetamine (MDMA, ecstasy), other stimulants, or opiates in an attempt to compensate for the common side effect of erectile dysfunction, a combination known as "sextasy", "rockin' and rollin'", "hammerheading", or "trail mix". [33] Mixing it with amyl nitrite, another vasodilator, is particularly dangerous and potentially fatal. The 2007 Ig Nobel Prize in aviation went to Patricia V. Agostino, Santiago A. Golombek of Universidad Nacional de Quilmes, Argentina, for their

discovery that sildenafil helps treat

Pregnancy & Lactation

[11] It was approved for medical use in the United States and in the European Union in 1998. [5][8][11][12] In 2023, it was the 151st most commonly prescribed medication in the United States, with more than 3 million prescriptions. [13][14] It is available as a generic medication. [15][16] In the United Kingdom, it is available as a pharmacy medicine. The primary indication of sildenafil is treatment of erectile dysfunction (inability to sustain a satisfactory erection to complete sexual intercourse).

Can you take Viagra if you have high blood pressure?

Its use is now one of best viagra for men the standard treatments for erectile dysfunction, including for males with diabetes mellitus. Tentative evidence suggests that sildenafil may help males who experience antidepressant-induced erectile dysfunction. While sildenafil improves some markers of disease in people with pulmonary arterial hypertension, it does not appear to affect the risk of death or serious side effects. Sildenafil and other PDE5 inhibitors are used off-label to alleviate vasospasm and treat severe ischemia and ulcers in fingers and toes for people with secondary Raynaud's phenomenon;[9][21] these drugs have moderate efficacy for reducing the frequency and duration of vasospastic episodes. [9] As of 2016,[update] their role more generally in Raynaud's was not clear. jet lag recovery in hamsters.

Professional athletes have been

Product Description

Sildenafil has shown some potential for improving exercise performance at high altitudes. However, its overall efficacy is not clear. Sildenafil has been studied for high-altitude pulmonary edema (HAPE), but its use is currently not recommended for that indication. In clinical trials, the most common adverse effects of sildenafil use included headache, flushing, indigestion, nasal congestion, and impaired vision, including photophobia and blurred vision. [4] Some sildenafil users have complained of seeing everything tinted blue (cyanopsia).

What to do if you think you’ve taken too much Viagra

[24] This cyanopsia can be explained because sildenafil, while selective for PDE5, does have some affinity for PDE6, which is the phosphodiesterase found in the retina. Patients thus taking the drug may experience colorvision abnormalities. Some complained of blurriness and loss of peripheral vision. In July 2005, the US Food and Drug Administration (FDA) updated labeling for tadalafil (Cialis), vardenafil (Levitra), and sildenafil (Viagra) to reflect a small number of post-marketing reports of sudden vision loss, while acknowledging that "...it is not possible to determine whether these oral medicines for erectile dysfunction were the cause of the loss of eyesight or whether the problem is related to other factors such as high blood pressure or diabetes, or to a combination of these problems. "[25] A careful review of pooled data from clinical trials containing well documented information about the dose and duration of exposure to the drug for a large number of patients, yields no evidence for an increased risk of non-arteritic anterior ischemic optic neuropathy or other adverse ocular events associated with PDE5 inhibitor use. documented using sildenafil, believing the

opening of their blood vessels will enrich their muscles.

Overdose/Missed Dose

Always ask your health care professional for complete information about this product and your specific health needs. Selected from NATIONAL DRUG DATA FILE (NDDF) data included with permission and copyrighted by First Databank, Inc., 2019. This copyrighted material has been downloaded from a licensed data provider. The above information is intended to supplement, not substitute for, the expertise and judgment of your health care professional. You should consult your health care professional before taking any drug, changing your diet, or commencing or discontinuing any course of treatment.

Less common

Just been sildenafil by my Gp and have concerns about side effects especially vision and heart beat per minute Question posted · View member profile · Last updated The information on this page reflects personal experiences shared by our community members. It is not reviewed for medical accuracy and should not replace professional medical advice. My PCP prescribed me a 100mg dose! I was also worried about potential side effects. I split each pill into 1/4’s, so I cut them in half then in half again. In turn, they believe it will enhance their performances.

Acetildenafil and other synthetic structural analogs

• The 25 mg tablet is a precise dose manufactured under strict quality controls.
• PDE5 is found in other tissues, explaining side effects like nasal congestion.
• It can be prescribed for off-label uses under a doctor's careful supervision.
• Men with unstable angina or uncontrolled arrhythmias should not use.
• The medication can be detected in urine drug tests designed for sildenafil.
• It is not a steroid and does not build muscle.
• Can improve erectile function in men with ED due to multiple sclerosis.
• The placebo effect in ED treatment trials is often significant.
• A vacuum constriction device is a non-pharmacological alternative.
• The goal of treatment is satisfactory sexual intercourse for the patient/partner.
• Disposal via drug take-back programs is preferred over flushing or trash.

of sildenafil which are PDE5 inhibitors have

Non-medical use

Rare but serious adverse effects found through postmarketing surveillance include prolonged erections, severe low blood pressure, myocardial infarction (heart attack), ventricular arrhythmias, stroke, increased intraocular pressure, and sudden hearing loss. [4] In October 2007, the FDA announced that the labeling for all PDE5 inhibitors, including sildenafil, required a more prominent warning of the potential risk of sudden hearing loss. Care should be exercised by people who are also taking protease inhibitors for the treatment of HIV infection. Protease inhibitors inhibit the metabolism of sildenafil, effectively multiplying the plasma levels of sildenafil, increasing the incidence and severity of side effects. Those using protease inhibitors are recommended to limit their use of sildenafil to no more than one 25 mg dose every 48 hours.

Viagra and herbs and supplements

[4] Other drugs that interfere with the metabolism of sildenafil include erythromycin and cimetidine, both of which can also lead to prolonged plasma half-life levels. The use of sildenafil and an α1 blocker (typically prescribed for hypertension or for urologic conditions, such as benign prostatic hypertrophy) at the same time may lead to low blood pressure, but this effect does not occur if they are taken at least 4 hours apart. Concomitant use of nitric oxide donors, organic nitrites and nitrates,[30] such as: nitroglycerinisosorbide mononitrateisosorbide dinitratesodium nitroprussidealkyl nitrites (commonly known as "poppers") Concomitant use of soluble guanylyl cyclase stimulators, such as riociguat Sildenafil should not be used if sexual activity is inadvisable due to underlying cardiovascular risk factors. Sildenafil's popularity with young adults has increased over the years. [32] Sildenafil's brand name, Viagra, is widely recognized in popular culture, and the drug's association with treating erectile dapoxetine viagra dysfunction has led to its recreational use. been found as adulterants in a

Further information

I still get pretty stuffed up and sometimes my face flushes, but that’s it. As my doctor told me, this is one of the safest medications in the world, they regularly prescribe it to elderly men who have had heart attacks. I’ve never had any vision, hearing, or fast heart beat issues. I’ve also found it temporarily reduces my blood pressure for about a day after I take a dose. We yellow viagra pill are all different, but this has been a good medication for me.

Serious side effects

Remember you can always start with a smaller dose and take more, but you can’t take less after a large dose. Sildenafil prescribing info & package insert (for Health Professionals) Try searching for what you seek or ask your own question. Sildenafil, sold under the brand name Viagra among others, is a medication used to treat erectile dysfunction and pulmonary arterial hypertension. [4][8] It is also sometimes used off-label for the treatment of certain symptoms in secondary Raynaud's phenomenon. [9] It is unclear if it is effective for treating sexual dysfunction in females. number of "herbal" aphrodisiac products sold over-the-counter.

What side effects could I expect?

[8] It can be taken orally (swallowed by mouth), intravenously (injection into a vein), or through the sublingual route (dissolved under the tongue). [8][10] Onset when taken orally is typically within twenty minutes and lasts for about two hours. Common side effects include headaches, heartburn, and flushed skin. [8] Caution is advised in those with cardiovascular disease. [8] Rare but serious side effects include vision problems, hearing loss, and prolonged erection (priapism) that can lead to damage to the penis.

Give yourself time for it to work

[8] Sildenafil should not be taken by people on nitric oxide donors such as nitroglycerin, as this may result in a serious drop in blood pressure. Sildenafil acts by blocking phosphodiesterase 5 (PDE5), an enzyme that promotes breakdown of cGMP, which regulates blood flow in the penis. [8] It requires sexual arousal to work, and does not by itself cause or increase sexual arousal. [8] It also results in dilation of the blood vessels in the lungs. Pfizer originally discovered the medication in 1989 while looking for a treatment for angina. [41] These analogs have not undergone any of the rigorous testing that drugs like sildenafil have passed,

• Sildenafil 25 mg is a cornerstone of oral pharmacotherapy for erectile dysfunction.
• Its mechanism involves enhancing the natural nitric oxide pathway.
• The tablet should be taken whole; do not crush or chew for intended effect.
• Men with pigmentary retinopathy should use alternative treatments.
• Can be used in men with Parkinson's disease, with physician guidance.
• The drug's success led to reduced stigma around seeking help for ED.
• It does not increase the risk of prostate cancer or benign prostatic hyperplasia.
• Combining with other ED treatments (like injections) can cause severe priapism.
• The psychological boost from successful treatment can improve relationship dynamics.
• It is essential to purchase from licensed, accredited pharmacies only.
• Regular reevaluation of the need for medication is part of good medical practice.

and thus have unknown side-effect profiles.

• Efficacy rates in clinical studies are often reported above 70% for appropriate patients.
• The 25 mg tablet is white or off-white for generic versions, not always blue.
• It is important to distinguish between Viagra (for ED) and Revatio (for PAH).
• Taking with a large glass of water can help mitigate potential headaches.
• Men with anatomical penile issues should have a urological evaluation first.
• The medication does not alter semen or impart any taste.
• Can be part of a treatment plan for ED related to antidepressant use (SSRI-induced).
• The psychological impact of successful treatment can be profound.
• It is not a treatment for premature ejaculation, though sometimes used off-label.
• Pharmacies are required to dispense the medication with a patient information leaflet.
• Traveling with a prescription requires keeping it in original labeled packaging.